[repost from the original post on beforeyoutakethatpill.com on October 3, 2007]

I was interviewed this morning by WLS-TV in Chicago about  the case of a man who admitted to killing his dermatologist, claiming that the acne medication Accutane made him do it. I referred to our study of 28 acne patients that showed that four months of treatment with accutane (but not antibiotics) resulted in a reduction in function of a brain area involved in mood and behavior called the orbitofrontal cortex.

There are also a number of cases of depression, suicide, violence and aggression associated with Accutane use, including “challenge-rechallenge” cases.  In addition there is a well established neuroscience of the retinoids  (a class of compounds of which Accutane is a member)  although the manufacturer of Accutane  (Roche) continues to deny a causal association and make arguments against an association as well as other effects to silence the issue. In fact, as reported in USA Today last year, one of the scientists working for Roche stated in a deposition that scientist Peter Schifferdecker in fact said that Accutane caused depression in some susceptible individuals, although the marketing team had the report changed since they thought it would “have an adverse effect on marketing.”

Strange business, indeed.

Update on the case of Hans Peterson’s homicide of Dr. David Cornbleet.

Doug Bremner MD recounts his experiences as an expert witness in drug safety litigation related to Accutane and suicide and depression in his 2011 book The Goose That Laid the Golden Egg.

One Response

  1. dubya_b

    There’s no other way to put it:
    Roche’s executives and marketing team are guilty of murder and the FDA are their happy accomplices. In the US, justice has been totally denied to those who have lost their health and the lives of their family members due to Accutane generics because Roche has more money, legal power, and influence over the medical community than the people who they have ruined , and David Chow, the former head of the Roacctutane Action Group, and many other young people in the UK have committed suicide due to the side effects of the drug and it has been wholly ignored.

    Someone eventually has to put a stop to this.